Pick Up Locations

[alderdust]

Hi Guys I am new to the game so go easy on me. I had a question about the Pick Up spaces in the game and how they are played...Do they mean that instead of using a search action inside the building the hero can choose to pick X item out of the hero deck instead? Do they have to be in a certain space within the building to pick up? And lastly once an item is picked up is it used up for the whole game or can multiple heroes pick up from that same spot?

Thanks!